Regulation Of gene expression in cystic fibrosis: implications for biology and therapeutics
نویسنده
چکیده
Approved: ___________________________________ Thesis Supervisor ____________________________________ Title and Department ____________________________________ Date 1 REGULATION OF GENE EXPRESSION IN CYSTIC FIBROSIS: IMPLICATIONS FOR BIOLOGY AND THERAPEUTICS by Shyam Ramachandran A thesis submitted in partial fulfillment of the requirements for the Doctor of Philosophy degree in Genetics in the Graduate College of The University of Iowa
منابع مشابه
A Review of The Role of The Microbiome on Immune Responses and Its Association With Cystic Fibrosis
In recent years, the microbiome has been recognized as a key regulator of immune responses. Evidence suggests that changes in the microbiome can lead to chronic disease and even exacerbation of the disease. Impairment of innate immunity resulting from microbial incompatibility may worsen host susceptibility to infection and exacerbate chronic lung diseases. Specific microbes play a key role in ...
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Cystic fibrosis (CF) is the most common autosomal recessive genetic disease, which is caused by defection in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene. CFTR gene codes chloride channels to modulate the homeostasis of epithelial environments. Defective CFTR affects various organs such as the lungs, pancreas, intestine, liver and skin; however, lung impairment is the mai...
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